|
Compounds |
Usual Daily
Dose |
Notes |
|
Stimulants |
|
Modafinil: Provigil® |
100-400mg |
Fewer sympathomimetic effects and side
effects, long duration of action, well tolerated but lower potency than
amphetamines |
|
Methylphenidate-HCl: Ritalin®, RitalinSR®
(extended release) |
10-60mg |
The regular formulation has a very short
duration of action. This is often useful when patients want to tailor
their treatment to their daily activities or combine stimulant
medication with sheduled napping. |
|
Dextroamphetamine-Sulfate:
Dexedrine®, Dextrostat®, Dexedrine-SR® |
5-60mg |
Variable duration of action (Urinary pH
and formulation), used in the US |
|
Methamphetamine-HCl: Desoxyn@ |
5-60mg |
Better distribution in the brain vs. the
periphery, more potent and effective than amphetamine, used in the U.S. |
|
Pemoline: Cylert® |
20-115mg |
Less potent and effective, long duration
of action, hepatotoxicity |
|
Mazindol: Sanorex® |
0.5-6mg |
Weakly effective, rarely used except in
the U.K. |
|
Anticataplectic Compounds |
|
Venlafaxine: EffexorSR® |
75-225mg |
New antidepressant, slow release
formulation, acting on both the serotoninergic and adrenergic system,
active on cataplexy; limited clinical experience but positive
preliminary results |
|
Atomoxetine: Strattera® |
10-80mg |
Norepinephrine reuptake inhibitor
|
|
Protriptyline: Triptil®,
Vivactil® |
5-60mg |
Anticholinergic effects (dry mouth,
blurred vision, constipation, etc.) at high doses, mild stimulant,
preferentially adrenergic effects |
|
Imipramine: Janimine@,
Tofranil® |
10-100mg |
Anticholinergic effects |
|
Desipramine: Norpramin®,
Pertofran® |
25-100mg |
Same as imipramine but more adrenergic
effects |
|
Clomipramine: Anafranil® |
10-150mg |
Very effective, mostly used in Europe |
|
Fluoxetine: Prozac® |
20-60mg |
Også kaldet lykkepiller |
| Reboxetine: Edronax® |
2-10mg |
Nyt antidepresiv middel som bl.a. er virksomt
mod katapleksi |
|
Hypnotic Compounds |
|
Sodium Oxybate: Xyrem® |
3-9g |
Short duration of action, resulting
anticatapletic effects during daytime. Helps alleviate daytime
sleepiness. Was approved on July 17, 2002. |
| Hypnotic Benzodiazepines |
|
Same as for the treatment of
non-narcoleptic insomnias |
|
